Cheapest one-way flights from Detroit to Panama City in May from $196

Best time to book flights for Detroit (DTW) to Panama City (PTY) flights at AirHint

AirHint found the following cheapest one-way flights from Detroit (DTW) to Panama City (PTY) in May 2025 (see full year).

One-Way flights

15 May Spirit Airlines
19 May Spirit Airlines
17 May Spirit Airlines

Also check the deals for return flights from Detroit to Panama City in May.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Panama City

Cheap car rent in Panama City