Cheapest one-way flights from Sao Paulo to Santiago in December from $105

Best time to book flights for Sao Paulo (GRU) to Santiago (SCL) flights at AirHint

AirHint found the following cheapest one-way flights from Sao Paulo (GRU) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

02 Dec Sky Airline direct
12 Dec Sky Airline direct
23 Dec LATAM Airlines Group
11 Dec Sky Airline direct
11 Dec LATAM Airlines Group
09 Dec Sky Airline direct
28 Dec Sky Airline direct
23 Dec Sky Airline direct
26 Dec Sky Airline direct
05 Dec Sky Airline direct

Also check the deals for return flights from Sao Paulo to Santiago in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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