Cheapest one-way flights from Madrid to Brussels in December from $58

Best time to book flights for Madrid (MAD) to Brussels (BRU) flights at AirHint

AirHint found the following cheapest one-way flights from Madrid (MAD) to Brussels (BRU) in December 2025 (see full year).

One-Way flights

31 Dec Ryanair direct
09 Dec Air Europa direct
30 Dec Iberia direct
26 Dec Iberia direct
18 Dec Ryanair direct
08 Dec Iberia
08 Dec Iberia direct
28 Dec Ryanair direct
19 Dec Ryanair direct
06 Dec Ryanair direct

Also check the deals for return flights from Madrid to Brussels in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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