Cheapest one-way flights from Madrid to Santiago in April from $410
AirHint found the following cheapest one-way flights from Madrid (MAD) to Santiago (SCL) in April 2025 (see full year).
One-Way flights
| 24 Apr | Iberia | direct | |
| 21 Apr | Iberia | direct | |
| 27 Apr | Iberia | direct | |
| 23 Apr | Iberia | direct | |
| 25 Apr | Iberia | direct | |
| 29 Apr | Iberia | direct | |
| 20 Apr | Iberia | direct | |
| 22 Apr | Iberia | direct | |
| 28 Apr | Ryanair | ||
| 26 Apr | Ryanair |
Also check the deals for return flights from Madrid to Santiago in April.
The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.
