Cheapest one-way flights from Madrid to Santiago in April from $391

Best time to book flights for Madrid (MAD) to Santiago (SCL) flights at AirHint

AirHint found the following cheapest one-way flights from Madrid (MAD) to Santiago (SCL) in April 2025 (see full year).

One-Way flights

20 Apr Iberia direct
07 Apr Iberia direct
08 Apr Iberia direct
06 Apr Iberia direct
22 Apr Iberia direct
18 Apr Iberia direct
15 Apr Iberia direct
24 Apr Iberia direct
02 Apr Iberia direct
16 Apr Iberia direct

Also check the deals for return flights from Madrid to Santiago in April.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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