Cheapest one-way flights from Madrid to Santa Cruz in December from $503

Best time to book flights for Madrid (MAD) to Santa Cruz (VVI) flights at AirHint

AirHint found the following cheapest one-way flights from Madrid (MAD) to Santa Cruz (VVI) in December 2025 (see full year).

One-Way flights

10 Dec Plus Ultra Lineas Aereas
03 Dec Plus Ultra Lineas Aereas
31 Dec Air Europa direct
01 Dec LATAM Airlines Group
21 Dec Boliviana de Aviacion direct
10 Dec Boliviana de Aviacion direct
20 Dec Avianca
03 Dec Iberia direct
01 Dec Air Europa direct

Also check the deals for return flights from Madrid to Santa Cruz in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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