Cheapest one-way flights from Madrid to Santa Cruz in April from $344

Best time to book flights for Madrid (MAD) to Santa Cruz (VVI) flights at AirHint

AirHint found the following cheapest one-way flights from Madrid (MAD) to Santa Cruz (VVI) in April 2025 (see full year).

One-Way flights

07 Apr Air Europa direct
27 Apr Air Europa direct
09 Apr Boliviana de Aviacion direct
18 Apr Boliviana de Aviacion direct
30 Apr Air Europa direct
29 Apr LATAM Airlines Group
14 Apr LATAM Airlines Group
12 Apr LATAM Airlines Group
25 Apr Ryanair
06 Apr LATAM Airlines Group

Also check the deals for return flights from Madrid to Santa Cruz in April.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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