Cheapest one-way flights from Chicago to Istanbul in April from $318

Best time to book flights for Chicago (MDW) to Istanbul (IST) flights at AirHint

AirHint found the following cheapest one-way flights from Chicago (MDW) to Istanbul (IST) in April 2025 (see full year).

One-Way flights

12 Apr Frontier Airlines
09 Apr Frontier Airlines
07 Apr Frontier Airlines
24 Apr Frontier Airlines
04 Apr Frontier Airlines
13 Apr Frontier Airlines
27 Apr Delta
23 Apr Frontier Airlines
30 Apr Frontier Airlines

Also check the deals for return flights from Chicago to Istanbul in April.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Istanbul

Cheap car rent in Istanbul