Cheapest one-way flights from Chicago to Istanbul in May from $428
AirHint found the following cheapest one-way flights from Chicago (MDW) to Istanbul (IST) in May 2025 (see full year).
One-Way flights
Also check the deals for return flights from Chicago to Istanbul in May.
The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.
