Cheapest one-way flights from Chicago to Prague in May from $374
AirHint found the following cheapest one-way flights from Chicago (MDW) to Prague (PRG) in May 2025 (see full year).
One-Way flights
| 16 May | Frontier Airlines | ||
| 19 May | Frontier Airlines | ||
| 20 May | Delta |
Also check the deals for return flights from Chicago to Prague in May.
The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.
