Cheapest one-way flights from Chicago to Rome in September from $293

Best time to book flights for Chicago (ORD) to Rome (FCO) flights at AirHint

AirHint found the following cheapest one-way flights from Chicago (ORD) to Rome (FCO) in September 2025 (see full year).

One-Way flights

15 Sep Icelandair
23 Sep Icelandair
18 Sep Turkish Airlines
11 Sep Turkish Airlines
01 Sep Turkish Airlines
06 Sep Icelandair
20 Sep Air Serbia
07 Sep Icelandair
23 Sep Iberia direct
20 Sep American Airlines direct

Also check the deals for return flights from Chicago to Rome in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Rome

Cheap car rent in Rome