Cheapest one-way flights from Chicago to Sao Paulo in December from $598

Best time to book flights for Chicago (ORD) to Sao Paulo (GRU) flights at AirHint

AirHint found the following cheapest one-way flights from Chicago (ORD) to Sao Paulo (GRU) in December 2025 (see full year).

One-Way flights

06 Dec Air Canada
19 Dec Avianca
06 Dec United direct
19 Dec United direct

Also check the deals for return flights from Chicago to Sao Paulo in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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