Cheapest one-way flights from Chicago to Istanbul in April from $353

Best time to book flights for Chicago (ORD) to Istanbul (IST) flights at AirHint

AirHint found the following cheapest one-way flights from Chicago (ORD) to Istanbul (IST) in April 2025 (see full year).

One-Way flights

28 Apr Icelandair
27 Apr Icelandair
22 Apr Icelandair
24 Apr Royal Jordanian
21 Apr Icelandair
23 Apr Qatar Airways
21 Apr Turkish Airlines direct
28 Apr Turkish Airlines direct
24 Apr Turkish Airlines direct
22 Apr Turkish Airlines direct

Also check the deals for return flights from Chicago to Istanbul in April.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Istanbul

Cheap car rent in Istanbul