Cheapest one-way flights from Prague to Madrid in October from $54

Best time to book flights for Prague (PRG) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest one-way flights from Prague (PRG) to Madrid (MAD) in October 2025 (see full year).

One-Way flights

15 Oct Ryanair direct
22 Oct Wizz Air Malta
13 Oct easyJet
03 Oct easyJet
22 Oct Vueling Airlines direct
14 Oct Ryanair direct
13 Oct Smart Wings direct
03 Oct Iberia direct

Also check the deals for return flights from Prague to Madrid in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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