Cheapest one-way flights from Panama City to Madrid in January from $571

Best time to book flights for Panama City (PTY) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest one-way flights from Panama City (PTY) to Madrid (MAD) in January 2026 (see full year).

One-Way flights

01 Jan Avianca
06 Jan Air Europa direct
01 Jan Air Europa direct

Also check the deals for return flights from Panama City to Madrid in January.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Madrid

Cheap car rent in Madrid