Cheapest one-way flights from San Diego to Santiago in December from $439

Best time to book flights for San Diego (SAN) to Santiago (SCL) flights at AirHint

AirHint found the following cheapest one-way flights from San Diego (SAN) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

22 Dec Copa
23 Dec Air Canada
21 Dec Porter Airlines (Canada) Ltd

Also check the deals for return flights from San Diego to Santiago in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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