Cheapest one-way flights from San Francisco to Rome in October from $297

Best time to book flights for San Francisco (SFO) to Rome (FCO) flights at AirHint

AirHint found the following cheapest one-way flights from San Francisco (SFO) to Rome (FCO) in October 2025 (see full year).

One-Way flights

09 Oct Vueling Airlines
04 Oct LEVEL
06 Oct TAP
03 Oct Hawaiian Airlines
26 Oct Alaska Airlines
06 Oct United direct
03 Oct ITA Airways direct
04 Oct United direct
09 Oct Lufthansa direct

Also check the deals for return flights from San Francisco to Rome in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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