Cheapest one-way flights from San Francisco to Rome in September from $393

Best time to book flights for San Francisco (SFO) to Rome (FCO) flights at AirHint

AirHint found the following cheapest one-way flights from San Francisco (SFO) to Rome (FCO) in September 2025 (see full year).

One-Way flights

29 Sep Alaska Airlines
06 Sep Scandinavian Airlines
09 Sep Alaska Airlines
19 Sep Alaska Airlines
01 Sep TAP
29 Sep ITA Airways direct
06 Sep ITA Airways direct
19 Sep ITA Airways direct
01 Sep ITA Airways direct
09 Sep ITA Airways direct

Also check the deals for return flights from San Francisco to Rome in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Rome

Cheap car rent in Rome