Cheapest one-way flights from Santa Cruz to Madrid in September from $636

Best time to book flights for Santa Cruz (VVI) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest one-way flights from Santa Cruz (VVI) to Madrid (MAD) in September 2025 (see full year).

One-Way flights

25 Sep Avianca
17 Sep GOL Linhas Aéreas
11 Sep GOL Linhas Aéreas
02 Sep GOL Linhas Aéreas
01 Sep GOL Linhas Aéreas
15 Sep Avianca
25 Sep Air Europa direct
16 Sep Air Europa direct
06 Sep Avianca
11 Sep Air Europa direct

Also check the deals for return flights from Santa Cruz to Madrid in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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