AirHint found the following cheapest return flights from Boston (BOS) to Prague (PRG) in October 2025 (see full year).

Return flights

19 Oct - 04 Nov	Iberia
22 Oct - 06 Nov	SWISS
13 Oct - 20 Oct	Icelandair
13 Oct - 21 Oct	Condor
22 Oct - 27 Oct	Iberia
14 Oct - 08 Nov	Air Canada
15 Oct - 21 Oct	Iberia
06 Oct - 15 Oct	Icelandair
15 Oct - 28 Oct	Lufthansa
08 Oct - 22 Oct	Lufthansa
21 Oct - 27 Oct	Iberia
08 Oct - 21 Oct	Aer Lingus
08 Oct - 16 Oct	Aer Lingus
27 Oct - 03 Nov	SWISS
18 Oct - 01 Nov	SWISS
31 Oct - 07 Nov	Lufthansa
26 Oct - 02 Nov	SWISS
25 Oct - 01 Nov	SWISS

Also check the deals for one-way flights from Boston to Prague in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Boston to Prague in October from $361

Return flights