AirHint found the following cheapest return flights from Guatemala City (GUA) to Santiago (SCL) in November 2025 (see full year).

Return flights

01 Nov - 08 Nov	Avianca
10 Nov - 17 Nov	Avianca
18 Nov - 22 Nov	Copa
02 Nov - 09 Nov	Copa
30 Nov - 11 Dec	Copa
30 Nov - 10 Dec	Copa
15 Nov - 23 Nov	Avianca
21 Nov - 06 Dec	Avianca
23 Nov - 29 Nov	Copa
22 Nov - 29 Nov	Copa
18 Nov - 24 Nov	Copa
18 Nov - 25 Nov	Copa
07 Nov - 22 Nov	Copa
27 Nov - 18 Dec	Copa

Also check the deals for one-way flights from Guatemala City to Santiago in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guatemala City to Santiago in November from $521

Return flights