Cheapest return flights from Houston to Panama City in April from $481

Best time to book flights for Houston (HOU) to Panama City (PTY) flights at AirHint

AirHint found the following cheapest return flights from Houston (HOU) to Panama City (PTY) in April 2025 (see full year).

Return flights

01 Apr - 15 Apr Spirit Airlines
01 Apr - 02 Apr Spirit Airlines
02 Apr - 06 Apr Spirit Airlines
30 Apr - 04 May Avianca
02 Apr - 15 Apr Spirit Airlines
01 Apr - 01 Apr Spirit Airlines
01 Apr - 15 Apr United direct
02 Apr - 15 Apr United direct
02 Apr - 06 Apr United direct
30 Apr - 04 May United direct
01 Apr - 01 Apr United direct
01 Apr - 02 Apr United direct

Also check the deals for one-way flights from Houston to Panama City in April.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Panama City

Cheap car rent in Panama City