Cheapest return flights from Istanbul to Madrid in October from $210

Best time to book flights for Istanbul (IST) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest return flights from Istanbul (IST) to Madrid (MAD) in October 2025 (see full year).

Return flights

13 Oct - 16 Oct Air Serbia
20 Oct - 24 Oct Air Serbia
16 Oct - 24 Oct Air Serbia
08 Oct - 13 Oct Wizz Air UK
15 Oct - 30 Oct Wizz Air UK
14 Oct - 23 Oct Aegean Airlines
13 Oct - 19 Oct Pegasus Airlines
25 Oct - 27 Oct Air Europa direct
20 Oct - 24 Oct Air Europa direct
14 Oct - 23 Oct Air Europa direct

Also check the deals for one-way flights from Istanbul to Madrid in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Madrid

Cheap car rent in Madrid