Cheapest return flights from Madrid to Panama City in December from $834

Best time to book flights for Madrid (MAD) to Panama City (PTY) flights at AirHint

AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in December 2025 (see full year).

Return flights

06 Dec - 27 Dec Air Europa direct
01 Dec - 08 Dec Air Europa direct
05 Dec - 10 Dec United
05 Dec - 13 Dec United
04 Dec - 13 Dec United
15 Dec - 29 Dec Iberia direct
22 Dec - 31 Dec Iberia direct
01 Dec - 10 Dec Iberia direct
06 Dec - 13 Dec KLM
19 Dec - 29 Dec Air Europa direct
29 Dec - 11 Jan Turkish Airlines
22 Dec - 05 Jan Iberia direct
16 Dec - 16 Jan Turkish Airlines
29 Dec - 10 Jan Iberia direct
24 Dec - 03 Jan Iberia direct
16 Dec - 16 Jan Air Europa direct
20 Dec - 03 Jan Iberia direct
20 Dec - 10 Jan Iberia direct
20 Dec - 11 Jan Turkish Airlines
29 Dec - 11 Jan Air Europa direct

Also check the deals for one-way flights from Madrid to Panama City in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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