Cheapest return flights from Madrid to Santiago in May from $789

Best time to book flights for Madrid (MAD) to Santiago (SCL) flights at AirHint

AirHint found the following cheapest return flights from Madrid (MAD) to Santiago (SCL) in May 2025 (see full year).

Return flights

01 May - 07 May Delta
20 May - 10 Jun Ryanair
22 May - 08 Jun LATAM Airlines Group
22 May - 12 Jun LATAM Airlines Group
18 May - 15 Jun LATAM Airlines Group
27 May - 05 Jun Ryanair
20 May - 05 Jun Ryanair
28 May - 05 Jun Ryanair
23 May - 11 Jun Ryanair
11 May - 25 May Iberia direct
09 May - 25 May Iberia direct
16 May - 29 May Iberia direct
19 May - 28 May LATAM Airlines Group
05 May - 09 Jun Ryanair
23 May - 14 Jun Ryanair
21 May - 28 May LATAM Airlines Group
23 May - 30 May Avianca
13 May - 18 May Avianca
13 May - 27 May Ryanair
20 May - 27 May Ryanair

Also check the deals for one-way flights from Madrid to Santiago in May.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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