Cheapest return flights from Madrid to Santa Cruz in October from $726

Best time to book flights for Madrid (MAD) to Santa Cruz (VVI) flights at AirHint

AirHint found the following cheapest return flights from Madrid (MAD) to Santa Cruz (VVI) in October 2025 (see full year).

Return flights

01 Oct - 25 Oct Air Europa direct
01 Oct - 20 Oct Air Europa direct
13 Oct - 20 Oct Air Europa direct
03 Oct - 04 Nov Air Europa direct
13 Oct - 04 Nov Air Europa direct
10 Oct - 03 Nov Air Europa direct
01 Oct - 01 Nov Air Europa direct
31 Oct - 10 Nov Air Europa direct
01 Oct - 02 Nov Avianca
10 Oct - 17 Oct Avianca
11 Oct - 04 Nov Avianca
08 Oct - 23 Oct Condor

Also check the deals for one-way flights from Madrid to Santa Cruz in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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