Cheapest return flights from Madrid to Santa Cruz in September from $693

Best time to book flights for Madrid (MAD) to Santa Cruz (VVI) flights at AirHint

AirHint found the following cheapest return flights from Madrid (MAD) to Santa Cruz (VVI) in September 2025 (see full year).

Return flights

14 Sep - 14 Oct Air Europa direct
28 Sep - 27 Oct Air Europa direct
15 Sep - 16 Oct Air Europa direct
21 Sep - 04 Oct Air Europa direct
18 Sep - 10 Oct LATAM Airlines Group
12 Sep - 02 Oct Air Europa direct
15 Sep - 30 Sep Air Europa direct
05 Sep - 30 Sep Air Europa direct
01 Sep - 22 Sep Air Europa direct
07 Sep - 25 Sep Air Europa direct
08 Sep - 29 Sep Air Europa direct
01 Sep - 30 Sep Air Europa direct
07 Sep - 28 Sep LATAM Airlines Group
06 Sep - 22 Sep Avianca
03 Sep - 18 Sep Condor
03 Sep - 27 Sep Condor

Also check the deals for one-way flights from Madrid to Santa Cruz in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santa Cruz

Cheap car rent in Santa Cruz