Cheapest return flights from Rio Negro to Guayaquil in April from $261

Best time to book flights for Rio Negro (MDE) to Guayaquil (GYE) flights at AirHint

AirHint found the following cheapest return flights from Rio Negro (MDE) to Guayaquil (GYE) in April 2025 (see full year).

Return flights

28 Apr - 02 May Avianca
18 Apr - 21 Apr Copa
04 Apr - 23 Apr Copa
18 Apr - 21 Apr Avianca direct
04 Apr - 23 Apr Avianca direct
14 Apr - 18 Apr Avianca
11 Apr - 20 Apr Avianca
10 Apr - 15 Apr Avianca
12 Apr - 20 Apr Avianca
11 Apr - 19 Apr Avianca
16 Apr - 20 Apr Avianca
28 Apr - 02 May Avianca direct

Also check the deals for one-way flights from Rio Negro to Guayaquil in April.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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