Cheapest return flights from Mexico City to Panama City in April from $387

Best time to book flights for Mexico City (MEX) to Panama City (PTY) flights at AirHint

AirHint found the following cheapest return flights from Mexico City (MEX) to Panama City (PTY) in April 2025 (see full year).

Return flights

02 Apr - 07 Apr Avianca
14 Apr - 21 Apr Copa direct
01 Apr - 05 Apr Viva Aerobus
22 Apr - 27 Apr Copa direct
01 Apr - 04 Apr Aeromexico
11 Apr - 21 Apr Copa direct
04 Apr - 17 Apr Copa direct
01 Apr - 04 Apr Copa direct
01 Apr - 05 Apr Copa direct
07 Apr - 12 Apr Copa direct
22 Apr - 24 May Copa direct
24 Apr - 01 May Copa direct
25 Apr - 02 May Copa direct

Also check the deals for one-way flights from Mexico City to Panama City in April.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Panama City

Cheap car rent in Panama City