Cheapest return flights from Mexico City to Santiago in October from $601

Best time to book flights for Mexico City (MEX) to Santiago (SCL) flights at AirHint

AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in October 2025 (see full year).

Return flights

20 Oct - 23 Oct LATAM Airlines Group
14 Oct - 28 Oct LATAM Airlines Group direct
22 Oct - 27 Oct LATAM Airlines Group direct
04 Oct - 21 Oct LATAM Airlines Group direct
15 Oct - 03 Nov LATAM Airlines Group
21 Oct - 03 Nov LATAM Airlines Group
24 Oct - 01 Nov LATAM Airlines Group
30 Oct - 08 Nov LATAM Airlines Group
02 Oct - 10 Oct Arajet
20 Oct - 23 Oct LATAM Airlines Group direct
15 Oct - 03 Nov LATAM Airlines Group direct
21 Oct - 03 Nov LATAM Airlines Group direct
24 Oct - 01 Nov LATAM Airlines Group direct
30 Oct - 08 Nov LATAM Airlines Group direct

Also check the deals for one-way flights from Mexico City to Santiago in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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