Cheapest return flights from Mexico City to Santiago in October from $645

Best time to book flights for Mexico City (MEX) to Santiago (SCL) flights at AirHint

AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in October 2025 (see full year).

Return flights

01 Oct - 08 Oct Avianca
02 Oct - 08 Oct Avianca
13 Oct - 17 Oct Avianca
18 Oct - 28 Oct Avianca
01 Oct - 08 Oct LATAM Airlines Group direct
18 Oct - 28 Oct LATAM Airlines Group direct
13 Oct - 17 Oct LATAM Airlines Group direct

Also check the deals for one-way flights from Mexico City to Santiago in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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