Cheapest return flights from Mexico City to Santiago in April from $387

Best time to book flights for Mexico City (MEX) to Santiago (SCL) flights at AirHint

AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in April 2025 (see full year).

Return flights

08 Apr - 23 Apr Arajet
15 Apr - 23 Apr Arajet
24 Apr - 08 May Arajet
01 Apr - 08 Apr Copa
01 Apr - 05 Apr Copa
06 Apr - 09 Apr Arajet
01 Apr - 13 Apr Copa
03 Apr - 15 Apr Copa
02 Apr - 09 Apr Copa
01 Apr - 15 Apr Copa
16 Apr - 25 Apr Copa
29 Apr - 08 May Copa
30 Apr - 07 May Viva Aerobus
30 Apr - 05 May Viva Aerobus
26 Apr - 24 May Viva Aerobus
22 Apr - 06 May LATAM Airlines Group direct
24 Apr - 08 May LATAM Airlines Group direct
30 Apr - 07 May LATAM Airlines Group direct
29 Apr - 08 May LATAM Airlines Group direct
16 Apr - 02 May LATAM Airlines Group direct

Also check the deals for one-way flights from Mexico City to Santiago in April.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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