Cheapest return flights from Panama City to Madrid in October from $740

Best time to book flights for Panama City (PTY) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in October 2025 (see full year).

Return flights

01 Oct - 18 Oct Air Europa direct
24 Oct - 27 Oct Air Europa direct
03 Oct - 21 Oct Air Europa direct
06 Oct - 18 Oct Air Europa direct
01 Oct - 22 Oct Air Europa direct
18 Oct - 31 Oct Air Europa direct
08 Oct - 22 Oct Air Europa direct
15 Oct - 31 Oct Air Europa direct
08 Oct - 15 Oct Air France
06 Oct - 15 Oct Air France
18 Oct - 08 Nov Iberia direct
24 Oct - 07 Nov Air Europa direct
19 Oct - 08 Nov Air Europa direct
31 Oct - 09 Nov Air France
31 Oct - 11 Nov Air France
31 Oct - 11 Nov Air Europa direct

Also check the deals for one-way flights from Panama City to Madrid in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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