Cheapest return flights from Panama City to Madrid in December from $747

Best time to book flights for Panama City (PTY) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in December 2025 (see full year).

Return flights

29 Dec - 19 Jan Air France
07 Dec - 30 Dec KLM
29 Dec - 19 Jan Iberia direct
08 Dec - 02 Jan Air France
11 Dec - 02 Jan KLM
25 Dec - 29 Dec KLM
12 Dec - 02 Jan KLM
07 Dec - 30 Dec Air Europa direct
07 Dec - 14 Dec Air Europa direct
24 Dec - 28 Dec Air Europa direct
25 Dec - 29 Dec Air Europa direct
08 Dec - 02 Jan Air Europa direct
11 Dec - 03 Jan Air Europa direct
11 Dec - 02 Jan Air Europa direct
12 Dec - 02 Jan Air Europa direct
01 Dec - 13 Dec Air France

Also check the deals for one-way flights from Panama City to Madrid in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Madrid

Cheap car rent in Madrid