Cheapest return flights from Panama City to Madrid in April from $678

Best time to book flights for Panama City (PTY) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in April 2025 (see full year).

Return flights

28 Apr - 05 May Iberia direct
24 Apr - 10 May Iberia direct
04 Apr - 26 Apr Air Europa direct
22 Apr - 30 Apr Air Europa direct
01 Apr - 15 Apr Air Europa direct
22 Apr - 14 May Air Europa direct
26 Apr - 22 May Iberia direct
21 Apr - 28 Apr Iberia direct
09 Apr - 24 Apr Iberia
13 Apr - 20 Apr KLM
16 Apr - 25 Apr Avianca
26 Apr - 15 May American Airlines
13 Apr - 20 Apr Air Europa direct
09 Apr - 24 Apr Air Europa direct

Also check the deals for one-way flights from Panama City to Madrid in April.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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