Cheapest one-way flights from Guayaquil to Santiago in September from $258

Best time to book flights for Guayaquil (GYE) to Santiago (SCL) flights at AirHint

AirHint found the following cheapest one-way flights from Guayaquil (GYE) to Santiago (SCL) in September 2025 (see full year).

One-Way flights

02 Sep Copa
26 Sep LATAM Airlines Group direct
02 Sep LATAM Airlines Group direct
27 Sep LATAM Airlines Group direct
06 Sep LATAM Airlines Group
05 Sep LATAM Airlines Group
07 Sep LATAM Airlines Group direct
05 Sep LATAM Airlines Group direct
06 Sep LATAM Airlines Group direct

Also check the deals for return flights from Guayaquil to Santiago in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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