Cheapest return flights from Guayaquil to Santiago in September from $482

Best time to book flights for Guayaquil (GYE) to Santiago (SCL) flights at AirHint

AirHint found the following cheapest return flights from Guayaquil (GYE) to Santiago (SCL) in September 2025 (see full year).

Return flights

25 Sep - 30 Sep Copa
14 Sep - 18 Sep LATAM Airlines Group
16 Sep - 02 Oct Copa
25 Sep - 30 Sep LATAM Airlines Group direct
13 Sep - 22 Sep LATAM Airlines Group
17 Sep - 04 Oct LATAM Airlines Group
01 Sep - 17 Sep LATAM Airlines Group direct
11 Sep - 14 Sep LATAM Airlines Group

Also check the deals for one-way flights from Guayaquil to Santiago in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago