Cheapest one-way flights from Istanbul to Madrid in September from $69

Best time to book flights for Istanbul (IST) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest one-way flights from Istanbul (IST) to Madrid (MAD) in September 2025 (see full year).

One-Way flights

30 Sep Pegasus Airlines direct
24 Sep Pegasus Airlines direct
26 Sep Pegasus Airlines direct
23 Sep Vueling Airlines
23 Sep Pegasus Airlines direct
13 Sep Pegasus Airlines
22 Sep Vueling Airlines
04 Sep Wizz Air
29 Sep Vueling Airlines
18 Sep Vueling Airlines

Also check the deals for return flights from Istanbul to Madrid in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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