Cheapest return flights from Istanbul to Madrid in September from $212

Best time to book flights for Istanbul (IST) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest return flights from Istanbul (IST) to Madrid (MAD) in September 2025 (see full year).

Return flights

22 Sep - 29 Sep Air Serbia
13 Sep - 17 Sep Air Serbia
11 Sep - 20 Sep Air Serbia
16 Sep - 23 Sep Air France
08 Sep - 15 Sep Air Serbia
08 Sep - 13 Sep Air Serbia
06 Sep - 12 Sep Wizz Air
06 Sep - 13 Sep Wizz Air
26 Sep - 28 Sep Wizz Air
03 Sep - 10 Sep Pegasus Airlines

Also check the deals for one-way flights from Istanbul to Madrid in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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