Cheapest one-way flights from Madrid to Istanbul in October from $68

Best time to book flights for Madrid (MAD) to Istanbul (IST) flights at AirHint

AirHint found the following cheapest one-way flights from Madrid (MAD) to Istanbul (IST) in October 2025 (see full year).

One-Way flights

20 Oct Pegasus Airlines direct
07 Oct Pegasus Airlines direct
15 Oct Pegasus Airlines direct
16 Oct Air Europa
30 Oct Air Europa
11 Oct Air Europa
12 Oct Pegasus Airlines direct
27 Oct Iberia Express
14 Oct Pegasus Airlines direct
17 Oct Pegasus Airlines direct

Also check the deals for return flights from Madrid to Istanbul in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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