Cheapest return flights from Madrid to Istanbul in October from $143

Best time to book flights for Madrid (MAD) to Istanbul (IST) flights at AirHint

AirHint found the following cheapest return flights from Madrid (MAD) to Istanbul (IST) in October 2025 (see full year).

Return flights

15 Oct - 21 Oct Pegasus Airlines direct
15 Oct - 20 Oct Pegasus Airlines direct
01 Oct - 05 Oct Pegasus Airlines direct
14 Oct - 21 Oct Pegasus Airlines direct
11 Oct - 19 Oct Air Europa
12 Oct - 19 Oct Iberia Express
02 Oct - 21 Oct Pegasus Airlines direct
15 Oct - 19 Oct Pegasus Airlines direct
15 Oct - 19 Oct Iberia Express
02 Oct - 20 Oct Pegasus Airlines direct
31 Oct - 06 Nov Air Europa
30 Oct - 03 Nov Air Europa
30 Oct - 03 Nov Turkish Airlines direct
31 Oct - 06 Nov Turkish Airlines direct

Also check the deals for one-way flights from Madrid to Istanbul in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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