Cheapest one-way flights from Madrid to Istanbul in September from $63

Best time to book flights for Madrid (MAD) to Istanbul (IST) flights at AirHint

AirHint found the following cheapest one-way flights from Madrid (MAD) to Istanbul (IST) in September 2025 (see full year).

One-Way flights

11 Sep Pegasus Airlines direct
17 Sep Pegasus Airlines direct
09 Sep Pegasus Airlines direct
15 Sep Pegasus Airlines direct
16 Sep Pegasus Airlines direct
23 Sep Pegasus Airlines direct
02 Sep Pegasus Airlines direct
24 Sep Pegasus Airlines direct
18 Sep Pegasus Airlines direct
05 Sep Pegasus Airlines direct

Also check the deals for return flights from Madrid to Istanbul in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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