Cheapest return flights from Madrid to Istanbul in September from $133

Best time to book flights for Madrid (MAD) to Istanbul (IST) flights at AirHint

AirHint found the following cheapest return flights from Madrid (MAD) to Istanbul (IST) in September 2025 (see full year).

Return flights

23 Sep - 30 Sep Pegasus Airlines direct
17 Sep - 30 Sep Pegasus Airlines direct
03 Sep - 30 Sep Pegasus Airlines direct
15 Sep - 24 Sep Pegasus Airlines
15 Sep - 24 Sep Pegasus Airlines direct
24 Sep - 15 Oct Pegasus Airlines direct
23 Sep - 15 Oct Pegasus Airlines
03 Sep - 27 Sep Pegasus Airlines
09 Sep - 16 Sep Pegasus Airlines
09 Sep - 18 Sep Pegasus Airlines
18 Sep - 23 Sep Air Europa
18 Sep - 23 Sep Pegasus Airlines direct
25 Sep - 02 Oct Vueling Airlines
23 Sep - 02 Oct Vueling Airlines
25 Sep - 07 Oct Vueling Airlines
25 Sep - 01 Oct Vueling Airlines
25 Sep - 09 Oct Vueling Airlines
25 Sep - 03 Oct Vueling Airlines
23 Sep - 07 Oct Vueling Airlines
23 Sep - 09 Oct Vueling Airlines

Also check the deals for one-way flights from Madrid to Istanbul in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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