Cheapest one-way flights from Madrid to Panama City in October from $576

Best time to book flights for Madrid (MAD) to Panama City (PTY) flights at AirHint

AirHint found the following cheapest one-way flights from Madrid (MAD) to Panama City (PTY) in October 2025 (see full year).

One-Way flights

20 Oct Air Europa direct

Also check the deals for return flights from Madrid to Panama City in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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