Cheapest one-way flights from Madrid to Panama City in September from $576

Best time to book flights for Madrid (MAD) to Panama City (PTY) flights at AirHint

AirHint found the following cheapest one-way flights from Madrid (MAD) to Panama City (PTY) in September 2025 (see full year).

One-Way flights

01 Sep Air Europa direct

Also check the deals for return flights from Madrid to Panama City in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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