Cheapest return flights from Madrid to Panama City in September from $659

Best time to book flights for Madrid (MAD) to Panama City (PTY) flights at AirHint

AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in September 2025 (see full year).

Return flights

05 Sep - 14 Sep KLM
22 Sep - 28 Sep Air France
05 Sep - 27 Sep KLM
19 Sep - 28 Sep KLM
13 Sep - 27 Sep KLM
22 Sep - 05 Oct Air France
26 Sep - 04 Oct KLM
26 Sep - 05 Oct KLM
27 Sep - 10 Oct Air France
14 Sep - 22 Sep KLM
10 Sep - 15 Sep KLM
15 Sep - 28 Sep KLM
04 Sep - 18 Sep KLM
08 Sep - 15 Sep KLM
23 Sep - 07 Oct KLM
19 Sep - 07 Oct KLM
22 Sep - 07 Oct Air France
21 Sep - 12 Oct Air France
13 Sep - 03 Oct KLM
19 Sep - 07 Oct Air Europa direct

Also check the deals for one-way flights from Madrid to Panama City in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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