Cheapest one-way flights from Madrid to San Francisco in October from $402

Best time to book flights for Madrid (MAD) to San Francisco (SFO) flights at AirHint

AirHint found the following cheapest one-way flights from Madrid (MAD) to San Francisco (SFO) in October 2025 (see full year).

One-Way flights

07 Oct Iberia
24 Oct Iberia
14 Oct Iberia
13 Oct Iberia
15 Oct Ryanair
06 Oct Iberia
26 Oct TAP
18 Oct Iberia
28 Oct TAP
25 Oct TAP

Also check the deals for return flights from Madrid to San Francisco in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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