Cheapest one-way flights from Mexico City to Panama City in May from $221

Best time to book flights for Mexico City (MEX) to Panama City (PTY) flights at AirHint

AirHint found the following cheapest one-way flights from Mexico City (MEX) to Panama City (PTY) in May 2025 (see full year).

One-Way flights

03 May Avianca
22 May Avianca
22 May Copa direct
05 May Copa direct
03 May Copa direct

Also check the deals for return flights from Mexico City to Panama City in May.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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