Cheapest one-way flights from Prague to Madrid in September from $63

Best time to book flights for Prague (PRG) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest one-way flights from Prague (PRG) to Madrid (MAD) in September 2025 (see full year).

One-Way flights

28 Sep Wizz Air Malta
06 Sep Wizz Air Malta
10 Sep Wizz Air Malta
26 Sep Vueling Airlines
10 Sep Ryanair direct
06 Sep Ryanair direct
21 Sep Vueling Airlines
28 Sep Smart Wings direct
04 Sep Ryanair direct
08 Sep Vueling Airlines

Also check the deals for return flights from Prague to Madrid in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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