Cheapest one-way flights from Panama City to Madrid in November from $551

Best time to book flights for Panama City (PTY) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest one-way flights from Panama City (PTY) to Madrid (MAD) in November 2025 (see full year).

One-Way flights

15 Nov Avianca
28 Nov Air Europa direct
29 Nov Air Europa direct
15 Nov Air Europa direct

Also check the deals for return flights from Panama City to Madrid in November.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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