Cheapest return flights from Guayaquil to Rio Negro in October from $248

Best time to book flights for Guayaquil (GYE) to Rio Negro (MDE) flights at AirHint

AirHint found the following cheapest return flights from Guayaquil (GYE) to Rio Negro (MDE) in October 2025 (see full year).

Return flights

20 Oct - 23 Oct Avianca
01 Oct - 04 Oct Avianca
10 Oct - 13 Oct Avianca
27 Oct - 31 Oct Avianca direct
07 Oct - 12 Oct Avianca
14 Oct - 19 Oct Avianca
09 Oct - 13 Oct Avianca
15 Oct - 20 Oct Avianca
08 Oct - 13 Oct Avianca
10 Oct - 13 Oct Avianca direct
30 Oct - 04 Nov Copa
30 Oct - 02 Nov Copa

Also check the deals for one-way flights from Guayaquil to Rio Negro in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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